On the upside, unlike previous GTA games Rockstar used a new method where if a file can't be called then it skips over it. The only downside is that since Rockstar replaced the multiplayer with their server/client GTA Online mode you can no longer make modifications and play online with friends the way you could with GTA IV. Nevertheless, seeing Niko opens up some nice possibilities for mods on the console version of GTA V. I'm not sure – and Raymnd doesn't say – if the file size limit (or directory size) has to stay the same in order to work, which is how it is with modding some other games or even previous GTA titles on home consoles.
Just like other GTA titles, you can't add new models or objects to the list. Raymnd from the Se7en Sins forums gives a brief walkthrough of how he went about replacing the files on his jTAG'd Xbox 360.